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Diagnosis: Membranous Glomerulonephritis - Lupus Nephritis Class V
This case was diagnosed as membranous GN, with a high suspicion of lupus nephritis. After confirming the diagnosis of SLE, it is confirmed class V lupus nephritis.
This case is very interesting because of the very prominent subepithelial deposits, still identifiable with light microscopy. In our experience, all cases with such prominent epithelial deposits have been shown to be lupus nephritis.
See the chapter: Lupus Nephritis... of our Tutorial.
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References
- Almaani S, Parikh SV. Membranous Lupus Nephritis: A Clinical Review. Adv Chronic Kidney Dis. 2019;26(5):393–403. [PubMed link]
- Kwon OC, Cho YM, Oh JS, et al. Renal flare in class V lupus nephritis: increased risk in patients with tubulointerstitial lesions. Rheumatol Int. 2019;39(12):2061–2067. [PubMed link]
- Tang KT, Tseng CH, Hsieh TY, Chen DY. Induction therapy for membranous lupus nephritis: a systematic review and network meta-analysis. Int J Rheum Dis. 2018;21(6):1163–1172. [PubMed link]
- Bomback AS. Nonproliferative Forms of Lupus Nephritis: An Overview. Rheum Dis Clin North Am. 2018;44(4):561–569. [PubMed link]
- Ward F, Bargman JM. Membranous Lupus Nephritis: The Same, But Different. Am J Kidney Dis. 2016;68(6):954–966. [PubMed link]