Case 115
With discussion
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CASE 115 (September 2015)

Clinical information

A 15-year-old woman with no medical history was evaluated by widespread edema, headache and coliuria. Blood pressure: 150/95. Hb: 12.7; Ht: 38.2% leukocytes: 9,800/mm2. Serum creatinine 1.9 mg/dL, BUN 29 mg/dL. Urinalysis: Proteins: 2.4 g/24h, erythrocytes: > 50/hpf, leukocytes: 4-5/hpf, nitrites: negative.

A renal biopsy was done, see the images.

Figure 1. H&E, X100.

Figure 2. H&E, X400.

Figure 3. PAS, X400.

Figure 4. Masson's trichrome stain, X400.

Figure 5. Methenaime-silver stain, X400.

Figure 6. Masson's trichrome stain, X1,000.

Figure 7. Immunofluorescence for IgG, X400.

Figure 8. Immunofluorescence for C3, X400.

Immunofluorescence for IgA, IgM, and C1q: Negative.

What is your diagnosis?

See diagnosis and discussion