Yu GZ, Guo L, Dong JF, et al. Persistent Hematuria and Kidney Disease Progression in IgA Nephropathy: A Cohort Study. Am J Kidney Dis. 2020;76(1):90-99. [PubMed link]
"Hematuria remission was associated with improved kidney outcomes in IgAN among patients with persistent proteinuria".
Su H, Yang M, Wan C, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020;98(1):219-227. [PubMed link]
Diffuse proximal tubule injury with the loss of brush border, non-isometric vacuolar degeneration, and even frank necrosis was observed. Occasional hemosiderin granules and pigmented casts were identified. There were prominent erythrocyte aggregates obstructing the lumen of capillaries without platelet or fibrinoid material. Electron microscopic examination showed clusters of coronavirus-like particles with distinctive spikes in the tubular epithelium and podocytes. Furthermore, the receptor of SARS-CoV-2, ACE2 was found to be upregulated in patients with COVID-19, and immunostaining with SARS-CoV nucleoprotein antibody was positive in tubules.
Miller SE, Brealey JK. Visualization of putative coronavirus in kidney. Kidney Int. 2020;98(1):231-232. [PubMed link]
In this letter, the authors discuss two previous papers (including the previous article) describing "viral particles" evidenced by EM in kidney, and they consider that them are not viral particles, instead subcellular organelles. A very interesting article on viral ultrastructural morphology.
Calomeni E, Satoskar A, Ayoub I, Brodsky S, Rovin BH, Nadasdy T. Multivesicular bodies mimicking SARS-CoV-2 in patients without COVID-19. Kidney Int. 2020;98(1):233-234. [PubMed link]
"Most of the published images depicting the suspected virus are very similar, if not identical, to multivesicular bodies (MVBs). MVBs have been well-known since the 1960s, however, their exact significance and function is unclear.
Coppo R, D'Arrigo G, Tripepi G, et al. Is there long-term value of pathology scoring in immunoglobulin A nephropathy? A validation study of the Oxford Classification for IgA Nephropathy (VALIGA) update. Nephrol Dial Transplant. 2020;35(6):1002-1009. [PubMed link]
M1, S1 and T1-T2 lesions as well as the whole MEST score were independently related with the combined endpoint, and there was no effect modification by age for these associations. Only T lesions were associated with the rate of eGFR loss in the whole cohort, whereas C showed this association only in patients not treated with immunosuppression.
Ahn W, Bomback AS. Approach to Diagnosis and Management of Primary Glomerular Diseases Due to Podocytopathies in Adults: Core Curriculum 2020. Am J Kidney Dis. 2020;75(6):955-964. [PubMed link]
Using case examples, the authors show how alternative classification schemes can assist not only diagnosis, but also long-term management of podocytopathies.
Farris AB, Moghe I, Wu S, et al. Banff Digital Pathology Working Group: Going digital in transplant pathology [published online ahead of print, 2020 Mar 17]. Am J Transplant. 2020 [PubMed link]
The Banff Digital Pathology Working Group (DPWG) was formed in the time leading up to and during the joint American Society for Histocompatibility and Immunogenetics/Banff Meeting, September 23-27, 2019, held in Pittsburgh, Pennsylvania.
López V et al. Recommendations on management of the SARS-CoV-2 coronavirus pandemic (Covid-19) in kidney transplant patients. Nefrología (English Edition), Available online 6 April 2020 (Journal Pre-proof) [Website link, full text]
Rismanbaf A, Zarei S. Liver and Kidney Injuries in COVID-19 and Their Effects on Drug Therapy; a Letter to Editor. Arch Acad Emerg Med. 2020;8(1):e17. 2020 Mar 9. [PubMed link]
"Some articles have reported an increased incidence of acute renal injury following COVID-19, which could be due to the presence of SARS-CoV-2, the inflammation induced by the disease, or a synergistic effect of both on kidneys. Patients with acute renal injury have a higher mortality rate compared to other patients".
Perico L, Benigni A, Remuzzi G. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade [published online ahead of print, 2020 Mar 23]. Nephron. 2020;1–9. [PubMed link]
Yao XH, Li TY, He ZC, et al. [A Pathological Report of Three COVID-19 Cases by Minimally Invasive Autopsies] Zhonghua Bing Li Xue Za Zhi. 2020;49(0):E009.[PubMed link]
While the 2019-nCoV is mainly distributed in lung, the infection also involves in the damages of heart, vessels, liver, kidney and other organs. Degeneration and necrosis of parenchymal cells, formation of hyaline thrombus in small vessels, and pathological changes of chronic diseases were observed in other organs and tissues, while no evidence of coronavirus infection was observed in these organs.
Deng Y, Liu W, Liu K, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study [published online ahead of print, 2020 Mar 20]. Chin Med J (Engl). [PubMed link]
More patients in the death groups had complications such as ARDS, acute cardiac injury, acute kidney injury, shock, and DIC.
Guillen E, Pineiro GJ, Revuelta I, et al. Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? [published online ahead of print, 2020 Mar 20]. Am J Transplant. 2020 [PubMed link]
The authors report a case of a COVID-19 infection in a kidney transplant recipient, in which the first clinical symptoms were of gastrointestinal viral disease and fever, which further progressed to respiratory symptoms in 48h.
Chen Y, Guo Y, Pan Y, Zhao ZJ. Structure analysis of the receptor binding of 2019-nCoV [published online ahead of print, 2020 Feb 17]. Biochem Biophys Res Commun. 2020 [PubMed link]
Molecular modeling revealed that 2019-nCoV receptor binding domain RBD has a stronger interaction with angiotensin converting enzyme 2 (ACE2). Since ACE2 is predominantly expressed in intestines, testis, and kidney, fecal-oral and other routes of transmission are also possible.
Samih H Nasr Christopher P Larsen, Christophe Sirac, et al. Light Chain Only Variant of Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits Is Associated With a High Detection Rate of the Pathogenic Plasma Cell Clone. Kidney Int, 97(3), 589-601; Mar 2020 [PubMed link]
The authors describe the first series (17 cases) of PGNMID with deposition of monoclonal immunoglobulin light chain only (PGNMID-light chain).