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Diagnosis: Minimal Change Disease (in remission)
In this patient, given the delay in the biopsy, clinical and laboratory response had already been evidenced at the time of the procedure. Even so, it was decided to do the biopsy. Most capillaries analyzed by electron microscopy have normal appearance, with preserved pedicels, only in some small segments, as seen in Figure 7, there is still a loss of podocyte processes. All of the above indicates that it is a minimal change disease in remission.
See the chapter: Minimal Change Disease of our Tutorial.
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References
- Rovin BH, Caster DJ, Cattran DC, Gibson KL, Hogan JJ, Moeller MJ, Roccatello D, Cheung M, Wheeler DC, Winkelmayer WC, Floege J; Conference Participants. Management and treatment of glomerular diseases (part 2): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2019;95(2):281-295. [PubMed link]
- Mansur A. Minimal change Disease. In Medscape [Visit page (link)]:
- Bertelli R, Bonanni A, Caridi G, Canepa A, Ghiggeri GM. Molecular and Cellular Mechanisms for Proteinuria in Minimal Change Disease. Front Med (Lausanne). 2018;5:170. [PubMed link].