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Diagnosis: PTLD
This case was dignosed for our hematopathologist as monomorphic post-tranasplant lymphoproliferative disease (PTLD), type diffuse large B-cell lymphoma. The patient is now on treatment that includes decreasing immunosuppression.
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References
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Petrara MR, Giunco S, Serraino D, Dolcetti R, De Rossi A. Post-transplant lymphoproliferative disorders: From epidemiology to pathogenesis-driven treatment. Cancer Lett. 2015;369(1):37-44. [PubMed Link]
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Montanari F, Radeski D, Seshan V, Alobeid B, Bhagat G, O'Connor OA. Recursive partitioning analysis of prognostic factors in post-transplant lymphoproliferative disorders (PTLD): a 120 case single institution series. Br J Haematol. 2015 Aug 6. [Epub ahead of print] [PubMed Link]
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Taylor E, Jones M, Hourigan MJ, Johnson DW, Gill DS, Isbel N, Hawley CM, Marlton P, Gandhi MK, Campbell SB, Mollee P. Cessation of immunosuppression during chemotherapy for post-transplant lymphoproliferative disorders in renal transplant patients. Nephrol Dial Transplant. 2015;30(10):1774-9. [PubMed link]
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Nassi L, Gaidano G. Hematol Oncol. Challenges in the management of post-transplant lymphoproliferative disorder. 2015;33 Suppl 1:96-9. [PubMed link]
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Jagadeesh D, Woda BA, Draper J, Evens AM. Post transplant lymphoproliferative disorders: risk, classification, and therapeutic recommendations. Curr Treat Options Oncol. 2012;13(1):122-36. [PubMed Link]