Case
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Diagnosis: Metanephric adenoma
Metanephric adenoma is a benign renal neoplasm derived or differentiated toward metanephric blastema.
The tumors are generally small, well circumscribed but unencapsulated. The cells are arranged in tubules, acinar structures, glomerulioid formations or solid areas. The tumor is juxtaposed directly against the normal renal parenchyma without an intervening fibrous capsule. The tumor may show solid growth pattern but true blastema is absent. The solid areas alternate with more tubular and organoid structures. No nucleoli are seen and none to very rare mitoses are present. There are not necrosis, hemorrhage, or any significant nuclear atypia. Calcifications or psamomma bodies are common. Metanephric adenoma can contain fibrous stroma and when abundant it may be called metanephric adenofibroma. In tumors with predominantly stroma elements with little epithelial structures the term metanephric stromal tumor is applied (From: Pathpedia).
See the Chapter Renal Neoplasms (Part 2) of our Tutorial (this chapter has only Spanish version).
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References
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Pathpedia. (Consulted: November 26, 2012)
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Choueiri TK, Cheville J, Palescandolo E, Fay AP, Kantoff PW, Atkins MB, McKenney JK, Brown V, Lampron ME, Zhou M, Hirsch MS, Signoretti S. BRAF Mutations in Metanephric Adenoma of the Kidney. Eur Urol. 2012 Nov;62(5):917-22. [PubMed link]
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Torricelli FC, Marchini GS, Campos RS, Gil AO. Metanephric Adenoma: clinical, imaging, and Histological findings. Clinics (Sao Paulo). 2011;66(2):359-61. [PubMed link] [Free full text]
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Obulareddy SJ, Xin J, Truskinovsky AM, Anderson JK, Franklin MJ, Dudek AZ. Metanephric adenoma of the kidney: an unusual diagnostic challenge. Rare Tumors. 2010 Jun 30;2(2):e38. [PubMed Link] [Free full text]
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Kuroda N, Tol M, Hiroi M, Enzan H. Review of metanephric adenoma of the kidney with focus on clinical and pathobiological aspects. Histol Histopathol. 2003 Jan;18(1):253-7. [PubMed link]
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Muir TE, Cheville JC, Lager DJ. Metanephric adenoma, nephrogenic rests, and Wilms' tumor: a histologic and immunophenotypic comparison. Am J Surg Pathol. 2001 Oct;25(10):1290-6. [PubMed link]