Nephropathology
   
Case 61
Diagnosis and discussion
 
     
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Diagnosis: Diabetic Nephropathy

Diabetic nephropathy is the leading cause of chronic renal failure in the Western societies. It is also one of the most significant long-term complications in terms of morbidity and mortality for individual patients with diabetes.

Diabetic nephropathy rarely develops before 10 years' duration of the disease, however, approximately 3% of newly diagnosed non – insulin-dependent diabetes mellitus (NIDDM) patients have overt nephropathy. In patients with recent diagnosis of NIDDM, the real time evolution of the disease is unknown. Then, in patients with recently diagnosed NIDDM and proteinuria we must think about the possibility of renal involvement for the diabetes.

To read more about diabetic nephropathy see the chapter: Renal involvement in diabetes mellitus and other metabolic diseases Amyloidosis... of our Tutorial.

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Bibliography

  • Valk EJ, Bruijn JA, Bajema IM. Diabetic nephropathy in humans: pathologic diversity. Curr Opin Nephrol Hypertens. 2011 Mar 18. [Epub ahead of print] [PubMed link]
  • Kelly KJ, Dominguez JH. Rapid progression of diabetic nephropathy is linked to inflammation and episodes of acute renal failure. Am J Nephrol. 2010;32(5):469-75. [PubMed link]
  • Fioretto P, Mauer M. Diabetic nephropathy: diabetic nephropathy-challenges in pathologic classification. Nat Rev Nephrol. 2010;6(9):508-10. [PubMed link]
  • Soman SS, Soman AS. Diabetic nephropathy. In e-Medicine. Consultes March 28th, 2011. Link: http://emedicine.medscape.com/article/238946-overview.
  • Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, Joh K, Noël LH, Radhakrishnan J, Seshan SV, Bajema IM, Bruijn JA; Renal Pathology Society. Pathologic classification of diabetic nephropathy. J Am Soc Nephrol. 2010;21(4):556-63. [PubMed link]
  • Huang F, Yang Q, Chen L, Tang S, Liu W, Yu X. Renal pathological change in patients with type 2 diabetes is not always diabetic nephropathy: a report of 52 cases. Clin Nephrol. 2007 ;67:293-7. [PubMed link]

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