Case
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Diagnosis: Renal Involvement for Diffuse B-Cell Lymphoma
Renal parenchymal involvement is uncommon in diffuse large B-cell lymphoma. In almost all cases, renal involvement appears to be a secondary process, either by direct extension from a retroperitoneal mass or via hematogenous spread in the setting of disseminated disease. Renal parenchymal involvement does not necessarily result in impaired organ function, suggesting that a number of patients may have microscopic, subclinical kidney involvement at diagnosis. (Villa D, et al. Diffuse large B-cell lymphoma with involvement of the kidney: outcome and risk of central nervous system relapse. Haematologica. 2011;96(7):1002-7. [PubMed link). In our patient, hepatosplenic involvement for the lymphoma was documented.
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References
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Li SJ, Chen HP, Chen YH, Zhang LH, Tu YM, Liu ZH. Renal involvement in non-Hodgkin lymphoma: proven by renal biopsy. PLoS One. 2014;14;9(4):e95190. [PubMed link]
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Villa D, Connors JM, Sehn LH, Gascoyne RD, Savage KJ. Diffuse large B-cell lymphoma with involvement of the kidney: outcome and risk of central nervous system relapse. Haematologica. 2011;96(7):1002-7. [PubMed link]
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Takei T, Uchiyama M. Diffuse large B-cell lymphoma with involvement of the kidney. BMJ Case Rep. 2012 Jul 3;2012. [PubMed link]
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Kowalewska J, Nicosia RF, Smith KD, Kats A, Alpers CE. Patterns of glomerular injury in kidneys infiltrated by lymphoplasmacytic neoplasms. Hum Pathol. 2011;42(6):896-903. [PubMed link]