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Diagnosis: Wilms tumor with chondroid differentiation

It is common in Wilms tumor find heterologous elements such as cartilage, muscle, bone, adipose tissue. These components have not implications on clinical presentation, prognosis or treatment.

A possible differencial diagnosis is teratoid Wilms’ tumor, in which there are significant heterologous components. Teratoid Wilms' tumor is defined as a tumor in which heterologous components like adipose tissue, glial tissue, muscles, cartilage or bone were at least 50% of the neoplasia. According to Beckwith criteria, a renal teratoma should be entirely within the renal capsule, and there should be clear evidence of renal component and other tissues (see references below).

See the Chapter Renal Neoplasms of our Tutorial (only Spanish version)

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References

• Mukhopadhyay B, Shukla RM, Mukhopadhyay M, Mandi S, Roy D, Bhattacharya MK. Teratoid Wilms' tumor - A rare renal tumor. Urol Ann. 2011;3(3):155-7. [PubMed link]  [Free Full text]

• Fernandes ET, Parham DM, Ribeiro RC, Douglass EC, Kumar AP, Wilimas J. Teratoid Wilms' tumor: the St Jude experience. J Pediatr Surg. 1988;23(12):1131-4. [PubMed link]
• Beckwith JB. Wilms' tumor and other renal tumors of childhood: a selective review from the National Wilms' Tumor Study Pathology Center. Hum Pathol. 1983;14(6):481-92. [PubMed link]

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