Case 123
With discussion
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CASE 123 (May 2016)

Clinical information

The patient is a 3-year-old girl with full nephrotic syndrome, steroid-resistant, symptoms of 3 months of evolution. Eight weeks of treatment with steroids, without response. Creatinine 0.9 mg/dL. Studies of autoimmunity and infections: Negative or normal. No pathological personal history. No known family history of kidney disease.

See the images of the renal biopsy.

Figure 1. H&E, X100.

Figure 2. H&E, X400.

Figure 3. Masson's trichrome stain, X400.

Figure 4.Masson's trichrome stain, X400.

Figure 5. Methenamine-silver, X400.

Figure 6. Methenamine-silver, X400.

Direct immunofluorescence for IgA, IgG, IgM, C3, and C1q: Negative.

What is your diagnosis?

See diagnosis and discussion