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Articles about kidney pathology, nephrology, and renal affectation in systemic diseases, published in the last months.

Here there are some articles, but if you are interested in a specific issue, please search in a more complete site (as PubMed)

 

Sawada A, Kawanishi K, Horita S, Omoto K, Okumi M, Shimizu T, Taneda S, Fuchinoue S, Ishida H, Honda K, Hattori M, Tanabe K, Koike J, Nagashima Y, Nitta K. Monoclonal immunoglobulin G deposits on tubular basement membrane in renal allograft: is this significant for chronic allograft injury? Nephrol Dial Transplant. 2019 Apr 1;34(4):711-717.
Among 7,177 renal allograft biopsy specimens, tubular basement membrane (TBM) deposits of IgG were found in 73 biopsies from 61 patients. In total, 13 biopsies from 10 patients showed monoclonal IgG TBM deposits. IgG1κ TBM deposits were associated with granular electron-dense deposits formation in TBM and IFTA progression. [PubMed link]

Couvrat-Desvergnes G, Foucher Y, Le Borgne F, Dion A, Mourad G, Garrigue V, Legendre C, Rostaing L, Kamar N, Kessler M, Ladrière M, Morelon E, Buron F, Giral M, Dantan E. Comparison of graft and patient survival according to the transplantation centre policy for 1-year screening biopsy among stable kidney recipients: a propensity score-based study. Nephrol Dial Transplant. 2019 Apr 1;34(4):703-711. [PubMed link]
The authors did not observe any significant difference for graft failure or patient survival between patients from centres with a 1-year screening biopsy policy and those from other centres.

Regunathan-Shenk R, Avasare RS, Ahn W, Canetta PA, Cohen DJ, Appel GB, Bomback AS. Kidney Transplantation in C3 Glomerulopathy: A Case Series. Am J Kidney Dis. 2019 Mar;73(3):316-323. [PubMed link]
Graft failure was more frequent in patients with DDD (6 of 7) than in patients with C3GN (3 of 12), occurred at a median time of 42 months posttransplantation, and was attributed to recurrent disease in half the failures.

Luciano RL, Moeckel GW. Update on the Native Kidney Biopsy: Core Curriculum 2019. Am J Kidney Dis. 2019 Mar;73(3):404-415. [PubMed link]
This Core Curriculum briefly outlines the history of the kidney biopsy, then discusses indications, complications, and specific procedural aspects.

Senev A, Coemans M, Lerut E, Van Sandt V, Daniëls L, Kuypers D, Sprangers B, Emonds MP, Naesens M. Histological picture of antibody-mediated rejection without donor-specific anti-HLA antibodies: Clinical presentation and implications for outcome. Am J Transplant. 2019 Mar;19(3):763-780. [PubMed link]
The authors found that using C4d deposition as alternative for the DSA criterion in the diagnosis of ABMR, as proposed in Banff 2017, did not contribute to the prognosis of graft function and graft failure, and that biopsies with ABMR but without detectable HLA‐DSA represent a distinct, often transient phenotype with superior allograft survival.

Choung HG, Bomback AS, Stokes MB, Santoriello D, Campenot ES, Batal I, Markowitz GS, D'Agati VD. The spectrum of kidney biopsy findings in patients with morbid obesity. Kidney Int. 2019 Mar;95(3):647-654. [PubMed link]
A study with 248 biopsies from morbidly obese patients. Obesity related glomerulopathy (ORG), defined as focal segmental glomerulosclerosis with glomerulomegaly or glomerulomegaly alone, was detected in 73 patients. In contrast, 167 patients had other kidney diseases alone, without ORG, most commonly (in descending order) diabetic nephropathy, acute tubular necrosis, hypertensive nephrosclerosis, IgA nephropathy, membranous nephropathy, and lupus nephritis.

Sethi S, Fervenza FC. Standardized classification and reporting of glomerulonephritis. Nephrol Dial Transplant. 2019 Feb 1;34(2):193-199. [PubMed link]
A review.

Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH. The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol. 2019 Jan;15(1):45-59. [PubMed link]
The International Kidney and Monoclonal Gammopathy Research Group (IKMG) met in April 2017 to refine the definition of MGRS and to update the diagnostic criteria for MGRS-related diseases. Accordingly, in this Expert Consensus Document, the IKMG redefines MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined haematological criteria for treatment of a specific malignancy.

Yazdani S, Callemeyn J, Gazut S, Lerut E, de Loor H, Wevers M, Heylen L, Saison C, Koenig A, Thaunat O, Thorrez L, Kuypers D, Sprangers B, Noël LH, Van Lommel L, Schuit F, Essig M, Gwinner W, Anglicheau D, Marquet P, Naesens M. Natural killer cell infiltration is discriminative for antibody-mediated rejection and predicts outcome after kidney transplantation. Kidney Int. 2019 Jan;95(1):188-198. [PubMed link]
The authors found increased NK cell infiltration in ABMR in comparison to TCMR and normal biopsies. NK cell infiltration was specifically associated with glomerulitis and peritubular capillaritis. These data suggest that NK cells play a central role in the pathophysiology of ABMR and graft failure after kidney transplantation.

Schinstock CA, Sapir-Pichhadze R, Naesens M, Batal I, Bagnasco S, Bow L, Campbell P, Clahsen-van Groningen MC, Cooper M, Cozzi E, Dadhania D, Diekmann F, Budde K, Lower F, Orandi BJ, Rowshani AT, Cornell L, Kraus E. Banff survey on antibody-mediated rejection clinical practices in kidney transplantation: Diagnostic misinterpretation has potential therapeutic implications. Am J Transplant. 2019 Jan;19(1):123-131. [PubMed link]
A survey of an international group of transplant nephrologists and pathologists reveals that the Banff antibody‐mediated rejection classification is vulnerable to misinterpretation, which may have patient management implications.

Mannon RB. The Banff schema for antibody-mediated rejection: Lost in translation? Am J Transplant. 2019 Jan;19(1):9-10. [PubMed link]
A comment on the previous paper.

Nankivell BJ, P'Ng CH, Chapman JR. Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection? Am J Transplant. 2019 Jan;19(1):132-144. [PubMed link]
The authors find isolated tubulitis without interstitial inflammation is predominantly due to reversible, nonimmune tubular injury, rather than borderline acute T cell rejection. They suggest its removal from the borderline category, and reinstatement of i1 as the diagnostic threshold.

Divers J, Langefeld CD, Lyles DS, Ma L, Freedman BI. Protective association between JC polyoma viruria and kidney disease. Curr Opin Nephrol Hypertens. 2019 Jan;28(1):65-69. [PubMed link]
Urinary tract JC poliomavirus replication is common and associates with lower rates of nephropathy. This relationship is observed in diverse settings. Results support a host immune system that fails to eradicate nonnephropathic viruses and is also less likely to manifest renal parenchymal inflammation.

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