Nephropathology Since 2006
Literature Monitor
Up to date
Versión en Español


Articles about kidney pathology, nephrology, and renal affectation in systemic diseases, published in the last months.

Here there are some articles, but if you are interested in a specific issue, please search in a more complete site (as PubMed)


Farris AB, Moghe I, Wu S, et al. Banff Digital Pathology Working Group: Going digital in transplant pathology [published online ahead of print, 2020 Mar 17]. Am J Transplant. 2020 [PubMed link]
The Banff Digital Pathology Working Group (DPWG) was formed in the time leading up to and during the joint American Society for Histocompatibility and Immunogenetics/Banff Meeting, September 23-27, 2019, held in Pittsburgh, Pennsylvania.

López V et al. Recommendations on management of the SARS-CoV-2 coronavirus pandemic (Covid-19) in kidney transplant patients. Nefrología (English Edition), Available online 6 April 2020 (Journal Pre-proof) [Website link, full text]

Rismanbaf A, Zarei S. Liver and Kidney Injuries in COVID-19 and Their Effects on Drug Therapy; a Letter to Editor. Arch Acad Emerg Med. 2020;8(1):e17. 2020 Mar 9. [PubMed link]
"Some articles have reported an increased incidence of acute renal injury following COVID-19, which could be due to the presence of SARS-CoV-2, the inflammation induced by the disease, or a synergistic effect of both on kidneys. Patients with acute renal injury have a higher mortality rate compared to other patients".

Perico L, Benigni A, Remuzzi G. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade [published online ahead of print, 2020 Mar 23]. Nephron. 2020;1–9. [PubMed link]
A review.

Yao XH, Li TY, He ZC, et al. [A Pathological Report of Three COVID-19 Cases by Minimally Invasive Autopsies] Zhonghua Bing Li Xue Za Zhi. 2020;49(0):E009.[PubMed link]
While the 2019-nCoV is mainly distributed in lung, the infection also involves in the damages of heart, vessels, liver, kidney and other organs. Degeneration and necrosis of parenchymal cells, formation of hyaline thrombus in small vessels, and pathological changes of chronic diseases were observed in other organs and tissues, while no evidence of coronavirus infection was observed in these organs.

Deng Y, Liu W, Liu K, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study [published online ahead of print, 2020 Mar 20]. Chin Med J (Engl). [PubMed link]
More patients in the death groups had complications such as ARDS, acute cardiac injury, acute kidney injury, shock, and DIC.

Guillen E, Pineiro GJ, Revuelta I, et al. Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? [published online ahead of print, 2020 Mar 20]. Am J Transplant. 2020 [PubMed link]
The authors report a case of a COVID-19 infection in a kidney transplant recipient, in which the first clinical symptoms were of gastrointestinal viral disease and fever, which further progressed to respiratory symptoms in 48h.

Chen Y, Guo Y, Pan Y, Zhao ZJ. Structure analysis of the receptor binding of 2019-nCoV [published online ahead of print, 2020 Feb 17]. Biochem Biophys Res Commun. 2020 [PubMed link]
Molecular modeling revealed that 2019-nCoV receptor binding domain RBD has a stronger interaction with angiotensin converting enzyme 2 (ACE2). Since ACE2 is predominantly expressed in intestines, testis, and kidney, fecal-oral and other routes of transmission are also possible.

Samih H Nasr Christopher P Larsen, Christophe Sirac, et al. Light Chain Only Variant of Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits Is Associated With a High Detection Rate of the Pathogenic Plasma Cell Clone. Kidney Int, 97(3), 589-601; Mar 2020 [PubMed link]
The authors describe the first series (17 cases) of PGNMID with deposition of monoclonal immunoglobulin light chain only (PGNMID-light chain).

Kidney Int, 97(3), 602-608 Mar 2020. Serum Amyloid P Deposition Is a Sensitive and Specific Feature of Membranous-Like Glomerulopathy With Masked IgG Kappa Deposits Christopher P Larsen, Shree G Sharma, Tiffany N Caza, Daniel J Kenan, Aaron J Storey, Ricky D Edmondson, Christian Herzog, John M Arthur. [PubMed link]
Immunostaining showed serum amyloid P colocalized with IgG in the glomeruli of membranous-like glomerulopathy with masked IgG kappa deposits but not with PLA2R-associated membranous glomerulopathy.

Vervaet BA, et al. Chronic Interstitial Nephritis in Agricultural Communities Is a Toxin-Induced Proximal Tubular Nephropathy. Kidney Int 2020 Feb; 97 (2), 350-369. [PubMed link]
The authors identified a unique constellation of proximal tubular cell findings including large dysmorphic lysosomes with a light-medium electron-dense matrix containing dispersed dark electron-dense non-membrane bound "aggregates", and conclude that "CINAC is a toxin-induced disease", although they do not do toxicological studies and show no relationship with any toxins.

Haas M. Uncovering the etiology of CINAC, a complex and mysterious renal syndrome: the invaluable role of histopathology and electron microscopy. Kidney Int 2020 Feb; 97 (2), 258-260. [PubMed link]
A comment on the previous paper.

Malvar A, Albertob V, Lococo B, et al. Kidney Biopsy-Based Management of Maintenance Immunosuppression Is Safe and May Ameliorate Flare Rate in Lupus Nephritis. Kidney Int 2020 Jan; 97 (1), 156-162. [PubMed link]
The authors postulate that continuing therapy for patients with persistent histologic activity on kidney biopsies done during maintenance and discontinuing therapy only for patients without histologic activity would minimize subsequent lupus nephritis flares.