Nephropathology
   
Case 106
With discussion
 
     
Versión en Español

CASE 106 (December 2014)

Clinical information

A five month-old girl presented with symptoms of malnutrition and severe urinary tract infection, with signs of sepsis and acute renal failure: serum creatinine 1.4 mg/dL. Both blood and urine cultures were positive for Escherichia coli, and antibiotic therapy was started. Severe, almost symmetrical, bilateral nephromegaly was evident on computed tomography (Figures 1 and 2). Voiding cystourethrography showed no urinary tract abnormalities.

Bilateral renal biopsies were performed.See the images.

Figure 1.

Figure 2.

Figure 3. H&E, X400.

Figure 4. H&E, X400.

Figure 5. H&E, X400.

Figure 6. H&E, X400.

Figure 7. PAS, X400.

Figure 8. PAS, X400.

What is your diagnosis?

See diagnosis and discussion

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