Go back to clinical information and images

Diagnosis: Crescentic IgA Nephropathy

While mesangial cell hypercellularity and matrix expansion are common in IgA nephropathy, additional glomerular pathology can include endocapillary proliferation, karyorrhexis and cellular crescents. Some authors have observed that ~20% of patients with IgA nephropathy had crescents on the initial biopsy, and that crescents were often associated with focal endocapillary proliferation or capillary‐wall necrosis, suggesting intense glomerular inflammation. Several studies have documented a higher incidence of hypertension and nephrotic range proteinuria in patients with the crescentic form of IgA nephropathy, suggesting that patients with this variant of the disease may have a worse prognosis (Tumlin JA, Hennigar RA.Clinical presentation, natural history, and treatment of crescentic proliferative IgA nephropathy. Semin Nephrol. 2004;24(3):256-68. [PubMed link] [Free full text]).

See the chapter: IgA Nephropaty of our Tutorial.

Go back to clinical information and images

References

• Lv J, Yang Y, Zhang H, Chen W, Pan X, Guo Z, Wang C, Li S, Zhang J, Zhang J, Liu L, Shi S, Wang S, Chen M, Cui Z, Chen N, Yu X, Zhao M, Wang H. Prediction of outcomes in crescentic IgA nephropathy in a multicenter cohort study. J Am Soc Nephrol. 2013;24(12):2118-25. [PubMed link]
• Graterol F, Navarro-Muñoz M, Ibernon M, López D, Troya MI, Pérez V, Bonet J, Romero R. Poor histological lesions in IgA nephropathy may be reflected in blood and urine peptide profiling. BMC Nephrol. 2013;14(1):82. [PubMed link]
• Jabur WL. Necrotic crescentic glomerulonephritis and IGA nephropathy: Lee-Haas classification revisited. Saudi J Kidney Dis Transpl. 2011;22(4):784-7. [PubMed link] [Full text link]
• Tumlin JA, Hennigar RA.Clinical presentation, natural history, and treatment of crescentic proliferative IgA nephropathy. Semin Nephrol. 2004;24(3):256-68. [PubMed link] [Free full text]

[Top]

Go back to clinical information and images