CASE 207 (May 2023)

Clinical information

A 12-year-old girl is evaluated for almost constant abdominal pain of 10 days' duration. On physical examination, a mass was palpable on the left flank. There is microhematuria. Ultrasound revealed a 14-cm renal mass, largely replacing the left kidney. The tomography study did not identify other thoracoabdominal lesions. The girl has normal growth and development. There is a family history of sickle cell anemia. Normal hemoleukogram.

A biopsy of the renal mass is performed.

Figure 1. H&E, X100.

Figure 2. H&E, X100.

Figure 3. H&E, X100.

Figure 4. H&E, X200.

Figure 5. H&E, X200.

Figure 6. H&E, X200.

Figure 7. H&E, X400.

Figure 8. H&E, X400.

Figure 9. H&E, X400.

Figure 10. H&E, X400.

Figure 11. Immunohistochemistry for cytokeratin cocktail, X400.

Figure 12. Immunohistochemistry for INI1 / SMARCB1, X400. Negative in neoplastic cells.

Immunostaining for WT1, S100, ALK, ACL, cyclin D1, BCOR, TFE3 and TFEB: Negative.

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