Nephropathology Since 2006
Case 162
With discussion
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CASE 162 (August 2019)

Clinical information

The patient is a 74-year-old man; two months of evolution of abdominal pain and weight loss. Image studies documented renal mass that replaced much of the left kidney. There was no relevant pathological history.

With the diagnosis of renal mass suspicious for malignancy, nephrectomy was done. See the images.

Case courtesy of Dr. Janeth Salazar Arias, Hospital Carlos Andrade Marin, Quito, Ecuador.

Figure 1.

Figure 2. H&E, X100.

Figure 3. H&E, X100.

Figure 4. H&E, X100.

Figure 5. H&E, X200.

Figure 6. H&E, X200.

Figure 7. H&E, X200.

Figure 8. H&E, X100.

Figure 9. H&E, X200.

Figure 10. Immunohistochemistry for Cytokeratin Cocktail, X100.

Figure 11. Immunohistochemistry for EMA, X100.

Figure 12. Immunohistochemistry for smooth muscle actin, X200.

Figure 13. Immunohistochemistry for CD34, X100.

Figure 14. Immunohistochemistry for CD31, X200.

Figure 15. Immunohistochemistry for Factor VIII, X200.

Immunohistochemistry for S100, HMB45, CD10, CK20, CK7, racemase, E-cadherin, RCC and inhibin: negative.

What is your diagnosis?

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