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En esta página aparecen artículos relevantes en Patología Renal, Nefrología y afectación renal en enfermedades sistémicas, publicados en los últimos meses.

Aquí aparecerán algunos de los artículos relacionados con estos temas, sin embargo, es imposible abarcarlos todos. Si usted está interesado en literatura actual de un tema específico, le sugerimos consultar otros buscadores (como PubMed)

Farris AB, Moghe I, Wu S, et al. Banff Digital Pathology Working Group: Going digital in transplant pathology [published online ahead of print, 2020 Mar 17]. Am J Transplant. 2020 [PubMed link]
The Banff Digital Pathology Working Group (DPWG) was formed in the time leading up to and during the joint American Society for Histocompatibility and Immunogenetics/Banff Meeting, September 23-27, 2019, held in Pittsburgh, Pennsylvania.

López V et al. Recomendaciones en el manejo de la pandemia por coronavirus SARS-CoV-2 (Covid-19) en pacientes con trasplante renal. Nefrología, Available online 6 April 2020 (Journal Pre-proof) [Website link, full text]

Rismanbaf A, Zarei S. Liver and Kidney Injuries in COVID-19 and Their Effects on Drug Therapy; a Letter to Editor. Arch Acad Emerg Med. 2020;8(1):e17. 2020 Mar 9. [PubMed link]
"Some articles have reported an increased incidence of acute renal injury following COVID-19, which could be due to the presence of SARS-CoV-2, the inflammation induced by the disease, or a synergistic effect of both on kidneys. Patients with acute renal injury have a higher mortality rate compared to other patients".

Perico L, Benigni A, Remuzzi G. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade [published online ahead of print, 2020 Mar 23]. Nephron. 2020;1–9. [PubMed link]
A review.

Yao XH, Li TY, He ZC, et al. [A Pathological Report of Three COVID-19 Cases by Minimally Invasive Autopsies] Zhonghua Bing Li Xue Za Zhi. 2020;49(0):E009.[PubMed link]
While the 2019-nCoV is mainly distributed in lung, the infection also involves in the damages of heart, vessels, liver, kidney and other organs. Degeneration and necrosis of parenchymal cells, formation of hyaline thrombus in small vessels, and pathological changes of chronic diseases were observed in other organs and tissues, while no evidence of coronavirus infection was observed in these organs.

Deng Y, Liu W, Liu K, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study [published online ahead of print, 2020 Mar 20]. Chin Med J (Engl). [PubMed link]
More patients in the death groups had complications such as ARDS, acute cardiac injury, acute kidney injury, shock, and DIC.

Guillen E, Pineiro GJ, Revuelta I, et al. Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? [published online ahead of print, 2020 Mar 20]. Am J Transplant. 2020 [PubMed link]
The authors report a case of a COVID-19 infection in a kidney transplant recipient, in which the first clinical symptoms were of gastrointestinal viral disease and fever, which further progressed to respiratory symptoms in 48h.

Chen Y, Guo Y, Pan Y, Zhao ZJ. Structure analysis of the receptor binding of 2019-nCoV [published online ahead of print, 2020 Feb 17]. Biochem Biophys Res Commun. 2020 [PubMed link]
Molecular modeling revealed that 2019-nCoV receptor binding domain RBD has a stronger interaction with angiotensin converting enzyme 2 (ACE2). Since ACE2 is predominantly expressed in intestines, testis, and kidney, fecal-oral and other routes of transmission are also possible.

Samih H Nasr Christopher P Larsen, Christophe Sirac, et al. Light Chain Only Variant of Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits Is Associated With a High Detection Rate of the Pathogenic Plasma Cell Clone. Kidney Int, 97(3), 589-601; Mar 2020 [PubMed link]
The authors describe the first series (17 cases) of PGNMID with deposition of monoclonal immunoglobulin light chain only (PGNMID-light chain).

Kidney Int, 97(3), 602-608 Mar 2020. Serum Amyloid P Deposition Is a Sensitive and Specific Feature of Membranous-Like Glomerulopathy With Masked IgG Kappa Deposits Christopher P Larsen, Shree G Sharma, Tiffany N Caza, Daniel J Kenan, Aaron J Storey, Ricky D Edmondson, Christian Herzog, John M Arthur. [PubMed link]
Immunostaining showed serum amyloid P colocalized with IgG in the glomeruli of membranous-like glomerulopathy with masked IgG kappa deposits but not with PLA2R-associated membranous glomerulopathy.

Vervaet BA, et al. Chronic Interstitial Nephritis in Agricultural Communities Is a Toxin-Induced Proximal Tubular Nephropathy. Kidney Int 2020; 97 (2), 350-369. [PubMed link]
The authors identified a unique constellation of proximal tubular cell findings including large dysmorphic lysosomes with a light-medium electron-dense matrix containing dispersed dark electron-dense non-membrane bound "aggregates", and conclude that "CINAC is a toxin-induced disease", although they do not do toxicological studies and show no relationship with any toxins.

Haas M. Uncovering the etiology of CINAC, a complex and mysterious renal syndrome: the invaluable role of histopathology and electron microscopy. Kidney Int 2020 Feb; 97 (2), 258-260. [PubMed link]
Un comemntario editorial sobre el artículo anterior.

Malvar A, Albertob V, Lococo B, et al. Kidney Biopsy-Based Management of Maintenance Immunosuppression Is Safe and May Ameliorate Flare Rate in Lupus Nephritis. Kidney Int 2020; 97 (1), 156-162. [PubMed link]
The authors postulate that continuing therapy for patients with persistent histologic activity on kidney biopsies done during maintenance and discontinuing therapy only for patients without histologic activity would minimize subsequent lupus nephritis flares.

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