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En esta página aparecen artículos relevantes en Patología Renal, Nefrología y afectación renal en enfermedades sistémicas, publicados en los últimos meses.

Aquí aparecerán algunos de los artículos relacionados con estos temas, sin embargo, es imposible abarcarlos todos. Si usted está interesado en literatura actual de un tema específico, le sugerimos consultar otros buscadores (como PubMed)

Trimarchi H. Crescents in primary glomerulonephritis: a pattern of injury with dissimilar actors. A pathophysiologic perspective. Pediatr Nephrol. 2022 Jun;37(6):1205-1214. [PubMed link]
"The pathophysiology of parietal cell proliferation may have dissimilar origins, underscoring the fact that the resultant crescents are a non-specific morphological pattern of glomerular injury with different implications in clinical prognosis in the scope of glomerular diseases". A review.

Adebayo OC, Van den Heuvel LP, Olowu WA, Levtchenko EN, Labarque V. Sickle cell nephropathy: insights into the pediatric population. Pediatr Nephrol. 2022 Jun;37(6):1231-1243. [PubMed link]
"Clinical presentation of sickle cell nephropathy (SCN) is age-dependent, with kidney dysfunction slowly beginning to develop from childhood, progressing to chronic kidney disease and kidney failure during the third and fourth decades of life. This review explores the epidemiology, pathology, pathophysiology, clinical presentation, and management of SCN by focusing on the pediatric population".

Dorval G, Servais A, Boyer O. The genetics of steroid-resistant nephrotic syndrome in children. Nephrol Dial Transplant. 2022 Apr;37(4):648-651. [PubMed link]
Una revisión concisa y clara.

Loupy A, Mengel M, Haas M. Thirty years of the International Banff Classification for Allograft Pathology: the past, present, and future of kidney transplant diagnostics. Kidney Int. 2022 Apr;101(4):678-691. [PubMed link]
"This review focuses on the major milestones in the development of the Banff classification of kidney allograft pathology and the evolution of the Banff process over the past 3 decades, with prospects for future advances and refinements".

Callemeyn J, Lamarthée B, Koenig A, Koshy P, Thaunat O, Naesens M. Allorecognition and the spectrum of kidney transplant rejection. Kidney Int. 2022 Apr;101(4):692-710. [PubMed link]
"Recientemente han surgido varias observaciones que cuestionan la dicotomización entre el rechazo mediado por células T y el rechazo mediado por anticuerpos...". Una excelente revisión.

Sim JJ, Shu YH, Hever A, O'Shaughnessy MM, Jacobsen SJ. Rates of Biopsy-Proven Pediatric Glomerulopathies in a Large Health System, 2000-2014. Am J Kidney Dis. 2022 Mar;79(3):453-455. [PubMed link]
A total of 411 biopsies met inclusion criteria. Lupus nephritis was the most common (21.7%), followed by MCD (13.4%) and focal segmental glomerulosclerosis (14.1%).

Heybeli C, Alexander MP, Bentall AJ, Amer H, Buadi FK, Dean PG, Dingli D, Dispenzieri A, El Ters M, Gertz MA, Issa NS, Kapoor P, Kourelis T, Kukla A, Kumar S, Lacy MQ, Lorenz EC, Muchtar E, Murray DL, Nasr SH, Prieto M, Rajkumar SV, Schinstock CA, Stegall MD, Warsame R, Leung N. Kidney Transplantation in Patients With Monoclonal Gammopathy of Renal Significance (MGRS)-Associated Lesions: A Case Series. Am J Kidney Dis. 2022 Feb;79(2):202-216. [PubMed link]
28 patients from 1987 through 2016; lesions including light-chain deposition disease, C3 glomerulopathy with monoclonal gammopathy, and light-chain proximal tubulopathy. Recurrence is very common in all MGRS-associated lesions after kidney transplant.

Watts AJB, Keller KH, Lerner G, Rosales I, Collins AB, Sekulic M, Waikar SS, Chandraker A, Riella LV, Alexander MP, Troost JP, Chen J, Fermin D, Yee JL, Sampson MG, Beck LH Jr, Henderson JM, Greka A, Rennke HG, Weins A. Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol. 2022 Jan;33(1):238-252. [PubMed link]
In two independent patient cohorts, the authors identified circulating nephrin autoantibodies during active disease that were significantly reduced or absent during treatment response in a subset of patients with minimal change disease.

Ye Q, Chen A, Lai EY, Mao J. Autoimmune Podocytopathies: A Novel Sub-Group of Diseases from Childhood Idiopathic Nephrotic Syndrome. J Am Soc Nephrol. 2022 Mar;33(3):653-654. [PubMed link]
In this letter in relation to the previous article the authors say that they have found "7 kinds of podocyte autoantibodies" related to onset of nephrotic syndrome, and approximately 60% of children with nephrotic syndrome have these podocytes autoantibodies.

Ibáñez Moreno JA, Bacca González JM, Taborda Murillo A, Ospina Ospina S, Arias LF. Compromiso renal en gammapatías monoclonales [Renal involvement in monoclonal gammopathies]. Rev Esp Patol. 2022 Jan-Mar;55(1):4-11. [PubMed link]
El diagnóstico histopatológico más frecuente fue riñón de mieloma (31,4% de los casos), siendo kappa la cadena ligera más frecuentemente depositada (65,6% de casos), seguido de amiloidosis AL (29,4%), donde predominó la cadena lambda en un 86,6% y la enfermedad por depósitos de cadenas ligeras (20,6%) con predominio de la cadena kappa: 66,6%.

Said SM, Best Rocha A, Valeri AM, Paueksakon P, Dasari S, Theis JD, Vrana JA, Obadina MO, Saghafi D, Alexander MP, Sethi S, Larsen CP, Joly F, Dispenzieri A, Bridoux F, Sirac C, Leung N, Fogo AB, McPhail ED, Nasr SH. The characteristics of patients with kidney light chain deposition disease concurrent with light chain amyloidosis. Kidney Int. 2022 Jan;101(1):152-163. [PubMed link]
"LCDD+AL could be caused by two pathological light chains produced by subclones stemming from one immunoglobulin light chain lambda or kappa rearrangement, with a distinct mutated complementary determining region".

Ronsin C, Georges M, Chapelet-Debout A, Augusto JF, Audard V, Lebourg L, Rubin S, Quemeneur T, Bataille P, Karras A, Daugas E, Titeca-Beauport D, Boffa JJ, Vigneau C, Halimi JM, Isnard-Bagnis C, Durault S, Renaudineau E, Bridoux F, Testa A, Le Quintrec M, Renaudin K, Fakhouri F. ANCA-Negative Pauci-immune Necrotizing Glomerulonephritis: A Case Series and a New Clinical Classification. Am J Kidney Dis. 2022 Jan;79(1):56-68.e1. [PubMed link]
A study with 74 cases. Three main subtypes of ANCA-negative PING were observed: infection-associated (n=9[12%]), malignancy-associated (n=6[8%]), and primary (n=57[77%]). It is a severe form of vasculitis with high morbidity and mortality rates despite immunosuppressive treatments.

Savige J, Harraka P. Pathogenic Variants in the Genes Affected in Alport Syndrome (COL4A3-COL4A5) and Their Association With Other Kidney Conditions: A Review. Am J Kidney Dis. 2021 Dec;78(6):857-864. [PubMed link]
"Massively parallel sequencing identifies pathogenic variants in the genes affected in Alport syndrome (COL4A3-COL4A5) in as many as 30% of individuals with focal and segmental glomerulosclerosis (FSGS), 10% of those with kidney failure of unknown cause, and 20% with familial immunoglobulin A (IgA) glomerulonephritis".

Álvarez Alvarado DA, Quintero Picón MA, Taborda-Murillo A, Ortiz-Arango N, Ospina Ospina S, Arias LF. Microscopía electrónica en biopsias renales: una evaluación de su utilidad en el siglo XXI [The relevance of electron microscopy in kidney biopsies to 21st century pathology]. Rev Esp Patol. 2021 Oct-Dec;54(4):234-241. [PubMed link] [Full text link].
En este trabajo llevado a acabo en nuestro centro, concluimos que La ME fue necesaria en menos de una quinta parte de las biopsias renales, siendo más útil en hematuria aislada y en enfermedades hereditarias. En síndrome nefrótico y biopsias de trasplante fue menos indispensable. Estos hallazgos pueden guiar protocolos de selección de casos en los que la ME podría considerarse una técnica no obligatoria.

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