Halloran PF, Madill-Thomsen KS, Pon S, Sikosana MLN, Böhmig GA, Bromberg J, Einecke G, Eskandary F, Gupta G, Hidalgo LG, Myslak M, Viklicky O, Perkowska-Ptasinska A; INTERCOMEX Investigators. Molecular diagnosis of ABMR with or without donor-specific antibody in kidney transplant biopsies: Differences in timing and intensity but similar mechanisms and outcomes. Am J Transplant. 2022 Aug;22(8):1976-1991. [PubMed link]
In a population of kidney transplant indication biopsies with a molecular diagnosis of antibody-mediated rejection, those without compared to those with donor-specific antibody typically occur earlier, are less active, and are more often C4d-negative but have similar graft loss risk and, according to genome-wide analyses, involve the same mechanisms.
Nankivell BJ, Shingde M, P'Ng CH. The Pathological and Clinical Diversity of Acute Vascular Rejection in Kidney Transplantation. Transplantation. 2022 Aug 1;106(8):1666-1676. [PubMed link]
A retrospective analysis of clinical and histological phenotypes of vascular rejection (VR) (n = 100) against rejection without arteritis (v0REJ, n = 540) and normal controls (n = 1108). The etiology was "pure" antibody-mediated VR (n = 21), mixed VR (n = 36), and "pure" T cell-mediated VR (n = 43). Isolated VR (n = 34, Banff i < 1 without tubulitis) comprised 24 T cell-mediated VR and 10 antibody-mediated VR, presenting with mild renal dysfunction, minimal Banff acute scores, and better graft survival compared with inflamed VR.
Santoro D, Debiec H, Longhitano E, Torreggiani M, Barreca A, Vegezzi E, Mazzeo A, Russo M, Piccoli GB, Toscano A, Ronco P. Contactin 1, a Potential New Antigen Target in Membranous Nephropathy: A Case Report. Am J Kidney Dis. 2022 Aug;80(2):289-94. [PubMed link].
"Anti-contactin 1 (CNTN1) antibody was detected by enzyme-linked immunosorbent assay at a 1:100 dilution of serum and shown to be mostly of IgG4 subclass by Western blot. CNTN1 antigen was colocalized with IgG4 within immune deposits by confocal microscopy".
Najafian B, Lusco MA, Alpers CE, Fogo AB. Approach to Kidney Biopsy: Core Curriculum 2022. Am J Kidney Dis. 2022 Jul;80(1):119-131. [PubMed link]
The authors first briefly discuss considerations for allocation and processing of kidney biopsies. They then present in outline form the differential diagnoses of a spectrum of patterns of injury and consideration for interpretation of specific lesions.
Haeuser L, Marchese M, Cone EB, Noldus J, Bayliss G, Kilbridge KL, Trinh QD. Nephrotoxicity of immune checkpoint inhibitor therapy: a pharmacovigilance study. Nephrol Dial Transplant. 2022 Jun 23;37(7):1310-1316. [PubMed link]].
"Using a pharmacovigilance method, we found increased odds of nephritis when examining renal adverse drug reactions associated with ICI therapy. Pembrolizumab, nivolumab and a combination of ipilimumab + nivolumab showed the highest odds".
Trimarchi H. Crescents in primary glomerulonephritis: a pattern of injury with dissimilar actors. A pathophysiologic perspective. Pediatr Nephrol. 2022 Jun;37(6):1205-1214. [PubMed link]
"The pathophysiology of parietal cell proliferation may have dissimilar origins, underscoring the fact that the resultant crescents are a non-specific morphological pattern of glomerular injury with different implications in clinical prognosis in the scope of glomerular diseases". A review.
Adebayo OC, Van den Heuvel LP, Olowu WA, Levtchenko EN, Labarque V. Sickle cell nephropathy: insights into the pediatric population. Pediatr Nephrol. 2022 Jun;37(6):1231-1243. [PubMed link]
"Clinical presentation of sickle cell nephropathy (SCN) is age-dependent, with kidney dysfunction slowly beginning to develop from childhood, progressing to chronic kidney disease and kidney failure during the third and fourth decades of life. This review explores the epidemiology, pathology, pathophysiology, clinical presentation, and management of SCN by focusing on the pediatric population".
Dorval G, Servais A, Boyer O. The genetics of steroid-resistant nephrotic syndrome in children. Nephrol Dial Transplant. 2022 Apr;37(4):648-651. [PubMed link]
Una revisión concisa y clara.
Loupy A, Mengel M, Haas M. Thirty years of the International Banff Classification for Allograft Pathology: the past, present, and future of kidney transplant diagnostics. Kidney Int. 2022 Apr;101(4):678-691. [PubMed link]
"This review focuses on the major milestones in the development of the Banff classification of kidney allograft pathology and the evolution of the Banff process over the past 3 decades, with prospects for future advances and refinements".
Callemeyn J, Lamarthée B, Koenig A, Koshy P, Thaunat O, Naesens M. Allorecognition and the spectrum of kidney transplant rejection. Kidney Int. 2022 Apr;101(4):692-710. [PubMed link]
"Recientemente han surgido varias observaciones que cuestionan la dicotomización entre el rechazo mediado por células T y el rechazo mediado por anticuerpos...". Una excelente revisión.