Nefropatología Desde 2006
   
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En esta página aparecen artículos relevantes en Patología Renal, Nefrología y afectación renal en enfermedades sistémicas, publicados en los últimos meses.

Aquí aparecerán algunos de los artículos relacionados con estos temas, sin embargo, es imposible abarcarlos todos. Si usted está interesado en literatura actual de un tema específico, le sugerimos consultar otros buscadores (como PubMed)

Hommos MS, Zeng C, Liu Z, Troost JP, Rosenberg AZ, Palmer M, Kremers WK, Cornell LD, Fervenza FC, Barisoni L, Rule AD. Global glomerulosclerosis with nephrotic syndrome; the clinical importance of age adjustment. Kidney Int. 2018 May;93(5):1175-1182. [PubMed link]
In patients with glomerulopathy that often presents with nephrotic syndrome, global glomerulosclerosis is clinically important only if it exceeds that expected for age.

Vazquez Martul E, Praga M. Nephropathology and nephrology. The need for a change. Nefrologia. 2018 May - Jun;38(3):247-249. [PubMed link]
A reflection on the integration of pathology and nephrology in medical centers.

Fukusumi Y, Zhang Y, Yamagishi R, Oda K, Watanabe T, Matsui K, Kawachi H. Nephrin-Binding Ephrin-B1 at the Slit Diaphragm Controls Podocyte Function through the JNK Pathway. J Am Soc Nephrol. 2018 May;29(5):1462-1474. [PubMed link]
Through interactions with nephrin, ephrin-B1 maintains the structure and barrier function of the slit diaphragm. Moreover, phosphorylation of ephrin-B1 and, consequently, JNK are involved in the development of podocyte injury. Another molecule more involved in the normal maintenance of the slit diaphragm.

Yeo SC, Cheung CK, Barratt J. Pediatr Nephrol. New insights into the pathogenesis of IgA nephropathy. 2018 May;33(5):763-777. [PubMed link]
A review.

Hasegawa J, Honda K, Omoto K, Wakai S, Shirakawa H, Okumi M, Ishida H, Fuchinoue S, Hattori M, Tanabe K. Clinical and Pathological Features of Plasma Cell-Rich Acute Rejection After Kidney Transplantation. Transplantation. 2018 May;102(5):853-859. [PubMed link]
The results indicated that plasma cell-rich acute rejection (PCAR) was an independent risk factor for allograft loss. PCAR presented with all types of rejection in the Banff 2015 criteria, and was associated with poor allograft survival.

Bomback AS, Santoriello D, Avasare RS, Regunathan-Shenk R, Canetta PA, Ahn W, Radhakrishnan J, Marasa M, Rosenstiel PE, Herlitz LC, Markowitz GS, D'Agati VD, Appel GB. C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy. Kidney Int. 2018 Apr;93(4):977-985. [PubMed link].
C3GN: 87 cases; dense deposit disease: 24 cases. Over an average of 72 months of follow-up, remission occurred in 38% of patients with C3GN and 25% of patients with dense deposit disease. Progression to late-stage CKD and ESRD was common, with no differences between C3GN (39%) and dense deposit disease (42%). The strongest predictors for progression were estimated glomerular filtration rate at diagnosis and tubular atrophy/interstitial fibrosis.

Šimunov B, Gunjača M, Čingel B, Škegro D, Knotek M. Safety of Outpatient Kidney Biopsies. Nephron. 2018 April;138(4):275-279. [PubMed link]
Seven hundred twenty-five biopsies performed in the outpatient setting; 592 transplant and 133 native biopsies. There were no major complications. A decline in Hb was observed in 72% of patients. In 10.1% patients there was >10% reduction in Hb level, with no evident bleeding, including by ultrasonography. In 2.5% of patients, macrohaematuria was present. No therapeutic interventions were required.

Colucci M, Corpetti G, Emma F, Vivarelli M. Immunology of idiopathic nephrotic syndrome. Pediatr Nephrol. 2018 Apr;33(4):573-584. [PubMed link]
A review.

Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, van Huyen JPD, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M. The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials. Am J Transplant. 2018 Feb;18(2):293-307. [PubMed link]
The classification was revised to include moderate i-IFTA plus moderate or severe tubulitis as diagnostic of chronic active TCMR. Now it is possible to diagnose ABMR with C4d or validated molecular assays, as potential alternatives and/or complements to DSAs.

Gutiérrez E, Praga M, Rivera F, Sevillano A, Yuste C, Goicoechea M, López-Gómez JM; all members of the Spanish Registry of Glomerulonephritis. Changes in the clinical presentation of immunoglobulin A nephropathy: data from the Spanish Registry of Glomerulonephritis. Nephrol Dial Transplant. 2018 Mar 1;33(3):472-477. [PubMed link]
The study was divided into five 4-year periods (1994-97, 1998-2001, 2002-05, 2006-09 and 2010-13); 2,961 biopsies. The prevalence of IgAN in Spain has remained stable over the years, patients are significantly older and present with significantly worse renal function in the last years.

Pakozdi A, Pyne D, Sheaff M, Rajakariar R. Utility of a repeat renal biopsy in lupus nephritis: a single centre experience. Nephrol Dial Transplant. 2018 Mar 1;33(3):507-513. [PubMed link]
Serial biopsies in 66 patients. Repeat renal biopsy is an important tool to guide management, in particular in those with initial class II or V who flare.

Fischer RSB, Vangala C, Truong L, Mandayam S, Chavarria D, Granera Llanes OM, Fonseca Laguna MU, Guerra Baez A, Garcia F, García-Trabanino R, Murray KO. Early detection of acute tubulointerstitial nephritis in the genesis of Mesoamerican nephropathy. Kidney Int. 2018 Mar;93(3):681-690. [PubMed link]
The authors report 11 patients who underwent renal biopsy that showed tubulointerstitial nephritis, with varying degrees of inflammation and chronicity. Interstitial cellular infiltrates mostly in the corticomedullary junction; neutrophilic accumulation in the tubular lumens; largely preserved glomeruli; few mild ischemic changes; and no immune deposits.

Bajema IM, Wilhelmus S, Alpers CE, Bruijn JA, Colvin RB, Cook HT, D'Agati VD, Ferrario F, Haas M, Jennette JC, Joh K, Nast CC, Noël LH, Rijnink EC, Roberts ISD, Seshan SV, Sethi S, Fogo AB. Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices. Kidney Int. 2018 Feb 16. [Epub ahead of print] [PubMed link]
The authors report detailed recommendations on issues for which they propose adjustments based on existing evidence and current consensus opinion.

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