Nephropathology Since 2006
Case 144
With discussion
Versión en Español

CASE 144 (February 2018)

Clinical information

The patient is a 67-year-old woman who presents with edema of a few weeks of evolution. Nephrotic syndrome is documented. Proteinuria: 9.7 g/24h. Normal renal function Negative autoimmunity tests. Normal serum complement. Studies for hepatotropic viruses, HIV and other infections: Negative.

A renal biopsy was done. See the images.

Figure 1. H&E , X100.

Figure 2. H&E, X400.

Figure 3. H&E, X400.

Figure 4. Masson's trichrome, X400.

Figure 5. Masson's trichrome, X400.

Figure 6. PAS, X400.

Figure 7. Methenamine-silver, X400.

Figure 8. Methenamine-silver, X400.

Figure 9. Direct immunofluorescence for IgG, X400.

Figure 10. Direct immunofluorescence for C3, X400.

Figure 11. Direct immunofluorescence for kappa light chain, X400.

Figure 12. Direct immunofluorescence for lambda light chain, X400.

Immunofluorescence for IgA, IgM and C1q: Negative.

What is your diagnosis?

See diagnosis and discussion